The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis

Nami, Mohammad; Kateb, Babak; Kamali, Ali-Mohammad; Kazemiha, Milad; Rao, KS; Chakrabarti, Tulika; Chakrabarti, Prasun

doi:10.30476/jamsat.2021.90464.1019

The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis

Document Type : Hypothesis

Authors

Mohammad Nami ¹

Babak Kateb ²

Ali-Mohammad Kamali ³

Milad Kazemiha ³

KS Rao ⁴

Tulika Chakrabarti ⁵

Prasun Chakrabarti ⁶

¹ Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz

² Society for Brain Mapping and Therapeutics, LA, United States

³ Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences

⁴ INDICASAT-AIP, 219 Clayton, City of Knowledge 084301103, Panama City, Republic of Panama

⁵ Department of Basic Science (Chemistry), Sir Padampat Singhania University, Udaipur, 3136022, Rajasthan, India

⁶ Provost, Techno India NJR Institute of Technology, Udaipur-313003, Rajasthan, India

10.30476/jamsat.2021.90464.1019

Abstract

The interaction between endocannabinoid (eCB) system with in key brain structures such as hippocampus, amygdala and prefrontal cortex and sleep deprivation (SD)-induced psychosis has been less studied. The present hypothesis revolves around the question whether altered chemical dynamics within the eCB system with the resultant impact on cannabinoid receptors in key cortical hubs would impact SD-induced psychosis-like symptoms. Having this investigated research is expected to pave the path towards identifying newer drug targets namely for schizophrenia. Research may be pursued by blocking the eCB system systemically after SD using eCB receptors antagonists to identify if SD still hampers the PPI. Continued research would also need to investigate if antipsychotic and cognitive enhancing drugs, such as cannabidiol and modafinil reverse the effects of SD upon PPI impairments.

Keywords

Endocanabinoid system

Sleep deprivation

Animal models

Psychosis-like symptoms

Drug development