TY - JOUR ID - 47364 TI - The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis JO - Journal of Advanced Medical Sciences and Applied Technologies JA - JAMSAT LA - en SN - 2423-5903 AU - Nami, Mohammad AU - Kateb, Babak AU - Kamali, Ali-Mohammad AU - Kazemiha, Milad AU - Rao, KS AU - Chakrabarti, Tulika AU - Chakrabarti, Prasun AD - Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz AD - Society for Brain Mapping and Therapeutics, LA, United States AD - Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences AD - INDICASAT-AIP, 219 Clayton, City of Knowledge 084301103, Panama City, Republic of Panama AD - Department of Basic Science (Chemistry), Sir Padampat Singhania University, Udaipur, 3136022, Rajasthan, India AD - Provost, Techno India NJR Institute of Technology, Udaipur-313003, Rajasthan, India Y1 - 2021 PY - 2021 VL - IS - SP - EP - KW - Endocanabinoid system KW - Sleep deprivation KW - Animal models KW - Psychosis-like symptoms KW - Drug development DO - 10.30476/jamsat.2021.90464.1019 N2 - The interaction between endocannabinoid (eCB) system with in key brain structures such as hippocampus, amygdala and prefrontal cortex and sleep deprivation (SD)-induced psychosis has been less studied. The present hypothesis revolves around the question whether altered chemical dynamics within the eCB system with the resultant impact on cannabinoid receptors in key cortical hubs would impact SD-induced psychosis-like symptoms. Having this investigated research is expected to pave the path towards identifying newer drug targets namely for schizophrenia. Research may be pursued by blocking the eCB system systemically after SD using eCB receptors antagonists to identify if SD still hampers the PPI. Continued research would also need to investigate if antipsychotic and cognitive enhancing drugs, such as cannabidiol and modafinil reverse the effects of SD upon PPI impairments. UR - https://jamsat.sums.ac.ir/article_47364.html L1 - ER -