@article { author = {Nami, Mohammad and Kateb, Babak and Kamali, Ali-Mohammad and Kazemiha, Milad and Rao, KS and Chakrabarti, Tulika and Chakrabarti, Prasun}, title = {The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis}, journal = {Journal of Advanced Medical Sciences and Applied Technologies}, volume = {}, number = {}, pages = {-}, year = {2021}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-5903}, eissn = {2538-4473}, doi = {10.30476/jamsat.2021.90464.1019}, abstract = {The interaction between endocannabinoid (eCB) system with in key brain structures such as hippocampus, amygdala and prefrontal cortex and sleep deprivation (SD)-induced psychosis has been less studied. The present hypothesis revolves around the question whether altered chemical dynamics within the eCB system with the resultant impact on cannabinoid receptors in key cortical hubs would impact SD-induced psychosis-like symptoms. Having this investigated research is expected to pave the path towards identifying newer drug targets namely for schizophrenia. Research may be pursued by blocking the eCB system systemically after SD using eCB receptors antagonists to identify if SD still hampers the PPI. Continued research would also need to investigate if antipsychotic and cognitive enhancing drugs, such as cannabidiol and modafinil reverse the effects of SD upon PPI impairments.}, keywords = {Endocanabinoid system,Sleep deprivation,Animal models,Psychosis-like symptoms,Drug development}, url = {https://jamsat.sums.ac.ir/article_47364.html}, eprint = {} }