Journal of Advanced Medical Sciences and Applied Technologies

Journal of Advanced Medical Sciences and Applied Technologies

Phenyl Ethanoid Glycoside from the Bark of Oroxylum indicum Vent: a Potential Inhibitor of DNA Topoisomerase IB of Leishmania donovani

Articles in Press

Document Type : Original Article

Authors
Tulika Chakrabarti 1
Sibabrata Mukhopadhyay 2
Prasun Chakrabarti 3
Gholamreza Hatam 4
Mohammad Nami 5
1 Department of Chemistry, Sir Padmapat Singhania University, Udaipur-313601, Rajasthan, India
2 Former Deputy Director and Scientist G, Indian Institute of Chemical Biology, lndia
3 Provost, Techno India NJR Institute of Technology, Udaipur-313003, Rajasthan, India
4 School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences
5 Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz
10.30476/jamsat.2021.91626.1022
Abstract
Though the Leishmania donovani complex species are morphologically indistinguishable, they can be differentiated by isoenzyme analysis, molecular methods, or monoclonal antibodies. Investigating the potential novel therapies against L. donovani has captivated research in the field of parasitology and biochemical pharmacy. In that vein, Phytochemical investigation of stem bark of Oroxylum indicum has resulted in the isolation of an interesting phenylethanoid glycoside 2-(3,4-dihydroxyphenyl)ethyl-O-α-L-rhamno-pyranosyl(1→3)-4-O-caffeoyl-β-D-glucopyranoside, first time isolated from this plant, along with two known flavone glycosides and three known flavones. The phenylethanoid glycoside was found to be a potent inhibitor of Leishmania Donovani through inhibition of LdDNA topoisomerase IB. Further research need to shed further light into the present topic.
Keywords
phenyl ethanoid glycoside
HMBC
DNA topoisomerase IB
plasmid relaxation
Journal of Advanced Medical Sciences and Applied Technologies

Articles in Press, Accepted Manuscript
Available Online from 17 June 2021