Document Type : Original Articles
Department of Ophthalmology, Poostchi Ophthalmology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Neuroscience laboratory-NSL (Brain, Cognition, and Behavior), School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Neuroscience Center, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Panama
Dana Brain Health Institute, Iranian Neuroscience Society, Fars Chapter, Shiraz, Iran
Objective: This study is aimed at profiling cognitive functions in patients with age-related
macular degeneration (AMD).
Method: This cross-sectional investigation enrolled 45 patients with AMD and 45 age- and
sex-matched controls. The overall cognitive performance in AMD sufferers versus control
subjects was assessed using the Persian version of Addenbrooke’s Cognitive Examination
battery (ACE-R). Subjects’ sleep quality was also evaluated using the Pittsburgh Sleep
Quality Index (PSQI). The mean global assessment and subscale scores were statistically
compared between groups.
Results: The mean global scores for ACE-R in AMD and control groups (80.4±12.3 and
86 ± 9.6, respectively) were found to be statistically different (p=0.018). On the other hand,
there was no significant difference (p=0.793) between the AMD and control groups in
terms of PSQI scores (9.7±2.8 and 9.8±2.8, respectively).
Conclusion: AMD patients seem to have cognitively underperformed in memory
and verbal fluency domains compared to the control group. Evidence on cognitive
impairments in patients with AMD may possibly herald neurocognitive insufficiencies
and have common pathological mechanisms with dementias.