Document Type : Original Articles
Lecturer, Faculty of Pharmacy, Lincoln University College, Selangor, Malaysia
Principal and Professor, Parul Institute of Pharmacy & Research, Gujarat, India
Department of Chemistry, Sir Padampat Singhania University, Udaipur 313601, Rajasthan, India
Provost and Institute Endowed Distinguished Senior Chair Professor, Techno India NJR Institute of Technology, Udaipur 313003, Rajasthan, India
Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Neuroscience laboratory-NSL (Brain, Cognition, and Behavior), School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Neuroscience Center, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Panama
Dana Brain Health Institute, Iranian Neuroscience Society, Fars Chapter, Shiraz, Iran
Introduction: Various plant species of genus Epipremnum have already been reported
to have different types of pharmacological activities. However, another plant of the same
genus Epipremnum aureum has not been scientifically exposed to a significant extent to
date. Although it contains many bioactives, it has only been studied for antidepressant
activity. The present study aims to evaluate the nootropic potential of standardized extract
of Epipremnum aureum against scopolamine-induced amnesia in experimental animals.
Method: The nootropic potential of Epipremnum aureum was evaluated using an elevated
plus maze and Morris water maze apparatus. A dose of 400mg/kg and 600mg/kg was used
to access the nootropic activity. Scopolamine (0.4 mg/kg) was used to induce amnesia in
mice. Additionally, the anti-acetylcholinesterase activity of the extract was evaluated by
measuring the level of acetylcholinesterase in the mice brain.
Result: Epipremnum aureum was found to increase memory and reverse the amnesic
action of scopolamine in a dose-dependent manner. In elevated plus maze and Morris
water maze, Epipremnum aureum decreased the transfer latency as compared to the control
group. Further biochemical investigation revealed an increased level of acetylcholine and
decreased level of TBARS resulting in reversing the effect of scopolamine in amnesic mice.
Conclusion: Epipremnum aureum showed positive results in reversing the amnesia
action of scopolamine which may be the probable mechanism for its memory retention
activity. Based on the experimental outcome, the present study provides a piece of scientific
evidence for the nootropic potential of Epipremnum aureum in experimental animals.