Document Type : Review Article
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Over the years and especially in recent decades, numerous articles in the field of in-vivo studies have been published; hence, the major part of medical discoveries that has led to increased life expectancy is as a result of these studies. The importance and inevitability of in-vivo studies have proven and no real alternative to animal models has been introduced so far. In this regard, the extent of authors' familiarity with in-vivo researches and the existence of biomedicalists for various measurements in animal models are highly important. Furthermore, resemble of animal models to human multifactorial diseases and the plenty of evidence for invasive interventions as well as the role of stress and genetic similarity should be considered in in-vivo studies. Therefore, due to waste of time and financial resources as well as animal rights and welfare, the existing animal models and methods should be constantly criticized. This article attempts to address this important issue of comparative biomedicalists.