A Hypothetical Animal Model for Psychosis Based on the Silencing of GABAergic System

Document Type : Hypothesis


1 Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Neuroscience, faculty of Advance Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran


Although many studies have highlighted the role of gamma-aminobutyric acid (GABA) in the pathophysiology of psychosis, there is no drug-induced animal model in which GABA is manipulated. In this article we propose a hypothetical animal model for psychosis based on the silencing GABAergic system.  The presentation also suggest Pre-Pulse Inhibition test as a preferred approach towards proving this hypothesis.


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