Mesenchymal Stem Cells as a Resource for Male Infertility Treatment

Document Type : Review Article

Authors

1 Department of tissue engineering and Applied cell science, Shiraz University of Medical Science, Shiraz, Iran

2 Department of biology, Collage of Science, Shiraz branch Islamic Azad University, Shiraz, Iran

Abstract

Male infertility due to decreased semen quality is a growing global problem. Commonly used strategies for treating infertility include medication, intrauterine insemination, and in vitro fertilization. In recent years, mesenchymal stem cells (MSCs) have created new opportunities to treat a variety of disorders, including infertility and new expectations for managing reproductive disabilities. Stem cells (SCs) are undifferentiated cells that are able to regenerate and proliferate and are also able to produce specialized cells under appropriate conditions. They are present in all stages of the fetus, embryo and adult and can multiply in different cells. While many questions remain about SCs, SCs have undoubtedly opened up new avenues for infertility treatment. In this review, we discuss and summarize different stem cell approaches to the treatment of male infertility to provide updates on SCs therapy research.

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