TY - JOUR ID - 42483 TI - A Paradigm Shift in Glioblastoma Treatment and Research: A Multi-mechanistic, Multi-agent Approach to Target Glioblastoma Multiforme JO - Journal of Advanced Medical Sciences and Applied Technologies JA - JAMSAT LA - en SN - 2423-5903 AU - Berg, John AD - Y1 - 2016 PY - 2016 VL - 2 IS - 4 SP - 323 EP - 326 KW - Fluoxetine KW - Fenofibrate KW - Cimetidine KW - Citrulline KW - Valacyclovir KW - Tadalafil KW - Glioblastoma multiforme DO - 10.18869/nrip.jamsat.2.4.323 N2 - The majority of patients with glioblastoma multiforme (GBM) suffer dismal outcomes. Adopting a broader, multi-mechanistic, multi-agent approach targeting GBM using readily available and fairly benign agents in combination with standard therapy may improve outcomes. Such agents include fluoxetine, fenofibrate, cimetidine, citrulline, valacyclovir, 1,3 1-6 beta glucan, and tadalafil, among others. In the context of in vitro and animal studies, these agents appear to target GBM cells and modify the tumor microenvironment. The current approach to GBM treatment focuses on limited molecular attributes of the condition. The following article highlights the relevance of the aforementioned agents in GBM treatment and proposes a multi-mechanistic, multi-agent paradigm shift, addressing a broader range of molecular attributes in the quest to improve patient outcomes. UR - https://jamsat.sums.ac.ir/article_42483.html L1 - https://jamsat.sums.ac.ir/article_42483_1ebb955a63ee234c2945b88f59071ef3.pdf ER -