TY - JOUR ID - 42476 TI - The Association of SMUG1 Gene Polymorphism with Age-related Macular Degeneration in Northwestern Iran JO - Journal of Advanced Medical Sciences and Applied Technologies JA - JAMSAT LA - en SN - 2423-5903 AU - Mehdizadeh, Faride AU - Bonyadi, Mortaza AU - Bonyadi, Mohammed Hussain AU - Javadzadeh, Alireza AD - Y1 - 2016 PY - 2016 VL - 2 IS - 3 SP - 257 EP - 261 KW - AMD KW - Polymorphism KW - SMUG1 gene KW - Oxidative stress DO - 10.18869/nrip.jamsat.2.3.257 N2 - Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss and debilitating disease in old age, which involves the central retina/macula among elderly patients. The genetic and environmental factors have important role in this multifactorial disease. Oxidative stress and DNA damages would have important impact on the onset and progression of AMD.  In this study, the possible association of c.-31A>G (rs3087404) polymorphism in the promoter region of SMUG1 gene with AMD disease was investigated. Fifty five AMD patients and 130 healthy age-, gender- and ethnicity-matched unrelated people as control group were genotyped by restriction fragment length polymorphism PCR (RFLP-PCR). Both groups were from Northwest of Iran (Tabriz).  Statistical analysis showed a significant association of AG genotype of this polymorphism with AMD. These results suggest a possible protective effect of this genotype for AMD disease (P=0.02, OR=0.574) among patients from Northwest of Iran. This genotype was observed more frequently in controls compared to the patients (59.23% v s 45.45%). UR - https://jamsat.sums.ac.ir/article_42476.html L1 - https://jamsat.sums.ac.ir/article_42476_a09b8d9850dc5068a930176742584f2c.pdf ER -